/* =========================================================
   Dr. Daniel E. Pleguezuelo · Inmunología clínica
   Hoja de estilos principal
   ========================================================= */
:root{
  --ink:#14171c;
  --ink-2:#2b3038;
  --muted:#5d6470;
  --line:#e4ded4;
  --paper:#fbf9f5;
  --ivory:#f3efe7;
  --white:#ffffff;
  --accent:#1f4fd1;       /* azul del logotipo */
  --accent-deep:#16389a;
  --gold:#a8844f;
  --night:#101318;
  --radius:18px;
  --shadow:0 1px 2px rgba(20,23,28,.04),0 12px 32px -12px rgba(20,23,28,.18);
  --serif:"Fraunces",Georgia,"Times New Roman",serif;
  --sans:"Inter",system-ui,-apple-system,"Segoe UI",Roboto,Arial,sans-serif;
  --wrap:1180px;
}
*{box-sizing:border-box}
html{scroll-behavior:smooth;-webkit-text-size-adjust:100%}
body{margin:0;background:var(--paper);color:var(--ink);font-family:var(--sans);font-size:17px;line-height:1.65;-webkit-font-smoothing:antialiased;text-rendering:optimizeLegibility}
img{max-width:100%;display:block}
a{color:var(--accent);text-underline-offset:3px}
a:hover{color:var(--accent-deep)}
h1,h2,h3,h4{font-family:var(--serif);font-weight:500;line-height:1.12;letter-spacing:-.015em;margin:0 0 .5em;color:var(--ink)}
h1{font-size:clamp(2.5rem,5.4vw,4.4rem)}
h2{font-size:clamp(1.9rem,3.4vw,2.9rem)}
h3{font-size:1.35rem}
p{margin:0 0 1.1em}
.wrap{width:100%;max-width:var(--wrap);margin:0 auto;padding:0 24px}
.eyebrow{display:inline-flex;align-items:center;gap:10px;font-size:.78rem;font-weight:600;letter-spacing:.16em;text-transform:uppercase;color:var(--gold);margin-bottom:18px}
.eyebrow::before{content:"";width:28px;height:1px;background:currentColor}
.lead{font-size:1.18rem;color:var(--ink-2);max-width:60ch}
.muted{color:var(--muted)}
.skip{position:absolute;left:-9999px}
.skip:focus{left:16px;top:16px;background:#fff;padding:8px 12px;z-index:100}

/* ---------- botones ---------- */
.btn{display:inline-flex;align-items:center;gap:10px;padding:14px 24px;border-radius:999px;font-weight:600;font-size:.96rem;text-decoration:none;transition:transform .2s ease,background .2s ease,color .2s ease,border-color .2s ease;border:1px solid transparent;cursor:pointer}
.btn svg{width:18px;height:18px}
.btn-primary{background:var(--ink);color:#fff}
.btn-primary:hover{background:var(--accent);color:#fff;transform:translateY(-1px)}
.btn-ghost{border-color:var(--ink);color:var(--ink)}
.btn-ghost:hover{background:var(--ink);color:#fff}
.btn-light{background:#fff;color:var(--ink)}
.btn-light:hover{background:var(--accent);color:#fff}
.btn-line-light{border-color:rgba(255,255,255,.35);color:#fff}
.btn-line-light:hover{border-color:#fff;background:rgba(255,255,255,.08);color:#fff}

/* ---------- cabecera ---------- */
.site-header{position:sticky;top:0;z-index:50;background:rgba(251,249,245,.86);backdrop-filter:saturate(1.4) blur(14px);-webkit-backdrop-filter:saturate(1.4) blur(14px);border-bottom:1px solid transparent;transition:border-color .3s}
.site-header.scrolled{border-bottom-color:var(--line)}
.nav{display:flex;align-items:center;justify-content:space-between;height:76px;gap:24px}
.brand{display:flex;align-items:center;gap:12px;text-decoration:none;color:var(--ink)}
.brand-mark{width:40px;height:40px;border-radius:50%;background:var(--ink);color:#fff;display:grid;place-items:center;font-family:var(--serif);font-size:1.02rem;letter-spacing:.02em;position:relative}
.brand-mark::after{content:"";position:absolute;right:3px;top:3px;width:8px;height:8px;background:var(--accent);border-radius:2px}
.brand-text{display:flex;flex-direction:column;line-height:1.15}
.brand-text strong{font-family:var(--serif);font-weight:500;font-size:1.08rem}
.brand-text span{font-size:.74rem;color:var(--muted);letter-spacing:.06em;text-transform:uppercase}
.menu{display:flex;align-items:center;gap:30px;list-style:none;margin:0;padding:0}
.menu a{color:var(--ink-2);text-decoration:none;font-size:.94rem;font-weight:500;position:relative}
.menu a:not(.btn)::after{content:"";position:absolute;left:0;bottom:-6px;height:1px;width:0;background:var(--ink);transition:width .25s}
.menu a:not(.btn):hover::after,.menu a[aria-current="page"]::after{width:100%}
.menu .lang{font-size:.8rem;font-weight:600;letter-spacing:.08em;border:1px solid var(--line);border-radius:999px;padding:4px 10px}
.menu .lang::after{display:none}
.menu .btn{padding:10px 18px;font-size:.9rem;color:#fff}
.nav-toggle{display:none;background:none;border:0;width:44px;height:44px;cursor:pointer;color:var(--ink)}
.nav-toggle svg{width:26px;height:26px}
@media (max-width:980px){
  .nav-toggle{display:grid;place-items:center}
  .menu{position:fixed;inset:76px 0 auto 0;flex-direction:column;align-items:flex-start;gap:0;background:var(--paper);padding:8px 24px 28px;border-bottom:1px solid var(--line);transform:translateY(-8px);opacity:0;pointer-events:none;transition:.25s}
  .menu.open{transform:none;opacity:1;pointer-events:auto}
  .menu li{width:100%;border-bottom:1px solid var(--line)}
  .menu li:last-child{border:0;padding-top:18px}
  .menu a:not(.btn){display:block;padding:14px 0;font-size:1.05rem}
  .menu a:not(.btn)::after{display:none}
  .menu .lang{display:inline-block;margin:10px 0}
}

/* ---------- hero ---------- */
.hero{position:relative;padding:72px 0 40px;overflow:hidden}
.hero::before{content:"";position:absolute;right:-240px;top:-160px;width:720px;height:720px;border-radius:50%;background:radial-gradient(circle at 30% 30%,rgba(31,79,209,.10),rgba(31,79,209,0) 62%);pointer-events:none}
.hero-grid{display:grid;grid-template-columns:1.12fr .88fr;gap:64px;align-items:center}
.hero h1 em{font-style:italic;color:var(--accent)}
.hero .lead{margin:22px 0 34px}
.hero-cta{display:flex;flex-wrap:wrap;gap:14px}
.portrait{position:relative;justify-self:end;width:100%;max-width:440px}
.portrait-frame{border-radius:240px 240px 24px 24px;overflow:hidden;aspect-ratio:4/5;background:var(--ivory);box-shadow:var(--shadow)}
.portrait-frame img{width:100%;height:100%;object-fit:cover;object-position:50% 22%}
.portrait-badge{position:absolute;left:-36px;bottom:40px;background:#fff;border-radius:16px;padding:16px 20px;box-shadow:var(--shadow);display:flex;gap:14px;align-items:center;max-width:270px}
.portrait-badge .num{font-family:var(--serif);font-size:2.2rem;line-height:1;color:var(--accent)}
.portrait-badge p{margin:0;font-size:.86rem;line-height:1.35;color:var(--ink-2)}
.portrait-deco{position:absolute;right:-18px;top:44px;width:86px;height:86px;border:1px solid var(--gold);border-radius:50%;opacity:.6}
.creds{display:grid;grid-template-columns:repeat(4,1fr);gap:0;margin-top:72px;border-top:1px solid var(--line);border-bottom:1px solid var(--line)}
.cred{padding:26px 22px;border-left:1px solid var(--line)}
.cred:first-child{border-left:0;padding-left:0}
.cred strong{display:block;font-family:var(--serif);font-weight:500;font-size:1.1rem;margin-bottom:4px}
.cred span{font-size:.88rem;color:var(--muted)}
@media (max-width:900px){
  .hero{padding:40px 0 24px}
  .hero-grid{grid-template-columns:1fr;gap:48px}
  .portrait{justify-self:center;max-width:360px}
  .portrait-badge{left:-8px}
  .creds{grid-template-columns:1fr 1fr;margin-top:48px}
  .cred:nth-child(3){border-left:0;padding-left:0}
  .cred:nth-child(n+3){border-top:1px solid var(--line)}
}
@media (max-width:520px){
  .creds{grid-template-columns:1fr}
  .cred{border-left:0;padding-left:0;border-top:1px solid var(--line)}
  .cred:first-child{border-top:0}
}

/* ---------- secciones ---------- */
.section{padding:110px 0}
.section-tight{padding:80px 0}
.section-head{display:flex;justify-content:space-between;align-items:flex-end;gap:40px;margin-bottom:56px}
.section-head p{max-width:46ch;margin:0;color:var(--muted)}
.bg-ivory{background:var(--ivory)}
@media (max-width:760px){.section{padding:76px 0}.section-head{flex-direction:column;align-items:flex-start;gap:12px;margin-bottom:36px}}

/* áreas */
.areas{display:grid;grid-template-columns:repeat(4,1fr);gap:20px}
.area{background:#fff;border:1px solid var(--line);border-radius:var(--radius);padding:30px 26px 28px;display:flex;flex-direction:column;transition:transform .25s,box-shadow .25s,border-color .25s}
.area:hover{transform:translateY(-4px);box-shadow:var(--shadow);border-color:transparent}
.area .ico{width:48px;height:48px;border-radius:14px;background:var(--ivory);display:grid;place-items:center;margin-bottom:26px;color:var(--accent)}
.area .ico svg{width:24px;height:24px}
.area h3{margin-bottom:10px}
.area p{font-size:.95rem;color:var(--muted);margin:0}
.area.featured{background:var(--ink);color:#fff;border-color:var(--ink)}
.area.featured h3{color:#fff}
.area.featured p{color:rgba(255,255,255,.72)}
.area.featured .ico{background:rgba(255,255,255,.08);color:#fff}
@media (max-width:1020px){.areas{grid-template-columns:1fr 1fr}}
@media (max-width:560px){.areas{grid-template-columns:1fr}}

/* estudios */
.split{display:grid;grid-template-columns:.9fr 1.1fr;gap:80px;align-items:center}
.split-media{position:relative;border-radius:24px;overflow:hidden;aspect-ratio:1/1;box-shadow:var(--shadow)}
.split-media img{width:100%;height:100%;object-fit:cover}
.tests{list-style:none;padding:0;margin:32px 0 0;counter-reset:t}
.tests li{counter-increment:t;display:grid;grid-template-columns:56px 1fr;gap:18px;padding:22px 0;border-top:1px solid var(--line)}
.tests li:last-child{border-bottom:1px solid var(--line)}
.tests li::before{content:"0" counter(t);font-family:var(--serif);font-size:1.4rem;color:var(--gold)}
.tests h3{font-size:1.2rem;margin-bottom:4px}
.tests p{margin:0;color:var(--muted);font-size:.96rem}
@media (max-width:900px){.split{grid-template-columns:1fr;gap:44px}.split-media{aspect-ratio:4/3}}

/* sobre mí / cita textual */
.about{display:grid;grid-template-columns:380px 1fr;gap:80px;align-items:center}
.about-photo{border-radius:24px;overflow:hidden;aspect-ratio:4/5;box-shadow:var(--shadow)}
.about-photo img{width:100%;height:100%;object-fit:cover;object-position:50% 15%}
blockquote.pull{font-family:var(--serif);font-size:clamp(1.45rem,2.4vw,2rem);line-height:1.3;font-weight:400;margin:0 0 30px;color:var(--ink);position:relative;padding-top:36px}
blockquote.pull::before{content:"“";position:absolute;top:-22px;left:-4px;font-size:5rem;color:var(--accent);line-height:1}
.facts{display:grid;grid-template-columns:1fr 1fr;gap:14px 30px;margin:32px 0 36px;padding:0;list-style:none}
.facts li{display:flex;gap:12px;align-items:flex-start;font-size:.95rem;color:var(--ink-2)}
.facts li::before{content:"";flex:0 0 7px;height:7px;margin-top:10px;border-radius:50%;background:var(--accent)}
@media (max-width:900px){.about{grid-template-columns:1fr;gap:40px}.about-photo{max-width:380px}.facts{grid-template-columns:1fr}}

/* cita */
.booking{background:var(--night);color:#fff;position:relative;overflow:hidden}
.booking::before{content:"";position:absolute;left:-200px;bottom:-300px;width:700px;height:700px;border-radius:50%;background:radial-gradient(circle,rgba(31,79,209,.28),rgba(31,79,209,0) 65%)}
.booking h2,.booking h3{color:#fff}
.booking .eyebrow{color:#cdb48a}
.booking .lead{color:rgba(255,255,255,.74)}
.booking-grid{position:relative;display:grid;grid-template-columns:1fr 1.05fr;gap:64px;align-items:start}
.channels{list-style:none;padding:0;margin:36px 0 0}
.channels li{border-top:1px solid rgba(255,255,255,.12)}
.channels li:last-child{border-bottom:1px solid rgba(255,255,255,.12)}
.channels a{display:grid;grid-template-columns:44px 1fr 24px;gap:16px;align-items:center;padding:20px 0;color:#fff;text-decoration:none}
.channels a:hover .arrow{transform:translateX(4px);color:#fff}
.channels .ci{width:44px;height:44px;border-radius:12px;background:rgba(255,255,255,.07);display:grid;place-items:center}
.channels .ci svg{width:20px;height:20px}
.channels strong{display:block;font-weight:600}
.channels span{font-size:.9rem;color:rgba(255,255,255,.6)}
.channels .arrow{color:rgba(255,255,255,.4);transition:.2s}
.widget-card{background:#fff;color:var(--ink);border-radius:22px;padding:26px 24px 22px;box-shadow:0 30px 60px -20px rgba(0,0,0,.5);min-height:420px}
.widget-card .wc-head{display:flex;align-items:center;justify-content:space-between;gap:12px;margin-bottom:14px;padding-bottom:14px;border-bottom:1px solid var(--line)}
.widget-card .wc-head h3{margin:0;font-size:1.25rem;color:var(--ink)}
.widget-card .wc-head span{font-size:.78rem;color:var(--muted);display:flex;align-items:center;gap:6px}
.widget-card .wc-head span::before{content:"";width:8px;height:8px;border-radius:50%;background:#1aa36b}
.widget-card .zl-url{display:inline-flex;margin:20px 0;padding:14px 22px;border-radius:999px;background:var(--ink);color:#fff;text-decoration:none;font-weight:600}
.widget-card iframe{width:100%!important;border:0}
.widget-note{font-size:.8rem;color:var(--muted);margin:12px 0 0}
@media (max-width:960px){.booking-grid{grid-template-columns:1fr;gap:44px}}

/* factor inmune */
.fi{display:grid;grid-template-columns:1.1fr .9fr;gap:0;background:#fff;border:1px solid var(--line);border-radius:28px;overflow:hidden}
.fi-body{padding:64px 56px}
.fi-media{background:var(--ivory)}
.fi-media img{width:100%;height:100%;object-fit:cover}
.fi-tags{display:flex;flex-wrap:wrap;gap:8px;margin:0 0 30px;padding:0;list-style:none}
.fi-tags li{font-size:.82rem;padding:6px 12px;border-radius:999px;background:var(--ivory);color:var(--ink-2)}
@media (max-width:900px){.fi{grid-template-columns:1fr}.fi-body{padding:40px 28px}.fi-media{aspect-ratio:16/10;order:-1}}

/* tarjetas de artículos */
.posts{display:grid;grid-template-columns:repeat(3,1fr);gap:24px}
.post-card{display:flex;flex-direction:column;background:#fff;border:1px solid var(--line);border-radius:var(--radius);padding:28px 26px 26px;text-decoration:none;color:var(--ink);transition:transform .25s,box-shadow .25s,border-color .25s}
.post-card:hover{transform:translateY(-4px);box-shadow:var(--shadow);border-color:transparent;color:var(--ink)}
.post-card .meta{display:flex;gap:10px;align-items:center;font-size:.78rem;color:var(--muted);margin-bottom:18px;flex-wrap:wrap}
.tag{font-size:.72rem;font-weight:600;letter-spacing:.06em;text-transform:uppercase;color:var(--accent);background:rgba(31,79,209,.07);padding:4px 10px;border-radius:999px}
.tag-video{color:#b3261e;background:rgba(179,38,30,.07)}
.post-card h3{font-size:1.28rem;margin-bottom:10px}
.post-card p{font-size:.93rem;color:var(--muted);margin:0 0 22px;flex:1}
.post-card .more{font-size:.88rem;font-weight:600;color:var(--ink);display:inline-flex;gap:8px;align-items:center}
.post-card:hover .more{color:var(--accent)}
@media (max-width:980px){.posts{grid-template-columns:1fr 1fr}}
@media (max-width:640px){.posts{grid-template-columns:1fr}}

/* filtros divulgación */
.filters{display:flex;flex-wrap:wrap;gap:8px;margin:0 0 36px}
.filters button{font:inherit;font-size:.88rem;border:1px solid var(--line);background:#fff;color:var(--ink-2);padding:8px 16px;border-radius:999px;cursor:pointer;transition:.2s}
.filters button:hover{border-color:var(--ink)}
.filters button[aria-pressed="true"]{background:var(--ink);border-color:var(--ink);color:#fff}

/* cabecera de página interior */
.page-hero{padding:72px 0 56px;border-bottom:1px solid var(--line)}
.page-hero .lead{margin-top:14px}
.crumbs{font-size:.84rem;color:var(--muted);margin-bottom:22px}
.crumbs a{color:var(--muted);text-decoration:none}
.crumbs a:hover{color:var(--ink)}

/* artículo */
.article-wrap{display:grid;grid-template-columns:minmax(0,720px) 1fr;gap:72px;padding:64px 0 100px}
.prose{font-size:1.08rem;line-height:1.8;color:var(--ink-2)}
.prose h2{font-size:1.8rem;margin:1.8em 0 .6em}
.prose h3{font-size:1.35rem;margin:1.6em 0 .5em}
.prose ul,.prose ol{padding-left:1.3em;margin:0 0 1.3em}
.prose li{margin-bottom:.5em}
.prose strong{color:var(--ink)}
.prose blockquote{margin:1.6em 0;padding:4px 0 4px 24px;border-left:2px solid var(--accent);font-family:var(--serif);font-size:1.25rem;color:var(--ink)}
.prose img{border-radius:14px;margin:1.6em 0}
.prose table{width:100%;border-collapse:collapse;margin:1.6em 0;font-size:.95rem}
.prose th,.prose td{border-bottom:1px solid var(--line);padding:10px 8px;text-align:left}
.video{position:relative;aspect-ratio:16/9;border-radius:18px;overflow:hidden;background:#000;margin:0 0 2em;box-shadow:var(--shadow)}
.video iframe{position:absolute;inset:0;width:100%;height:100%;border:0}
.aside{position:sticky;top:110px;align-self:start}
.aside-card{background:var(--ink);color:#fff;border-radius:20px;padding:28px}
.aside-card h3{color:#fff;font-size:1.3rem}
.aside-card p{color:rgba(255,255,255,.72);font-size:.94rem}
.aside-author{display:flex;gap:14px;align-items:center;margin-bottom:22px}
.aside-author img{width:56px;height:56px;border-radius:50%;object-fit:cover;object-position:50% 20%}
.aside-author strong{display:block;font-family:var(--serif);font-weight:500}
.aside-author span{font-size:.82rem;color:var(--muted)}
.aside-card .aside-author span{color:rgba(255,255,255,.6)}
.notice{margin-top:48px;padding:20px 22px;border-radius:14px;background:var(--ivory);font-size:.88rem;color:var(--muted)}
@media (max-width:980px){.article-wrap{grid-template-columns:1fr;gap:40px}.aside{position:static}}

/* trayectoria */
.timeline{list-style:none;margin:0;padding:0;position:relative}
.timeline::before{content:"";position:absolute;left:110px;top:8px;bottom:8px;width:1px;background:var(--line)}
.timeline li{display:grid;grid-template-columns:110px 1fr;gap:36px;padding:0 0 34px;position:relative}
.timeline li::after{content:"";position:absolute;left:105px;top:9px;width:11px;height:11px;border-radius:50%;background:var(--paper);border:2px solid var(--accent)}
.timeline .yr{font-family:var(--serif);color:var(--gold);font-size:1.02rem;padding-top:1px}
.timeline h3{font-size:1.15rem;margin-bottom:4px;font-family:var(--sans);font-weight:600;letter-spacing:0}
.timeline p{margin:0;color:var(--muted);font-size:.95rem}
@media (max-width:620px){.timeline::before{left:6px}.timeline li{grid-template-columns:1fr;gap:4px;padding-left:34px}.timeline li::after{left:1px}}
.pill-list{display:flex;flex-wrap:wrap;gap:10px;list-style:none;padding:0;margin:0}
.pill-list li{background:#fff;border:1px solid var(--line);padding:8px 14px;border-radius:999px;font-size:.9rem;color:var(--ink-2)}
.two-col{display:grid;grid-template-columns:1fr 1fr;gap:64px}
@media (max-width:860px){.two-col{grid-template-columns:1fr;gap:40px}}

/* banda CTA */
.cta-band{background:var(--accent);color:#fff;border-radius:28px;padding:56px;display:flex;justify-content:space-between;align-items:center;gap:32px;flex-wrap:wrap}
.cta-band h2{color:#fff;margin:0;font-size:clamp(1.6rem,2.8vw,2.3rem);max-width:22ch}
.cta-band .btn-light:hover{background:var(--ink)}
@media (max-width:640px){.cta-band{padding:36px 26px}}

/* pie */
.site-footer{background:var(--night);color:rgba(255,255,255,.66);padding:80px 0 36px;font-size:.93rem}
.site-footer a{color:rgba(255,255,255,.82);text-decoration:none}
.site-footer a:hover{color:#fff}
.foot-grid{display:grid;grid-template-columns:1.4fr 1fr 1fr 1fr;gap:48px;padding-bottom:56px;border-bottom:1px solid rgba(255,255,255,.1)}
.foot-grid h4{font-family:var(--sans);font-size:.76rem;letter-spacing:.14em;text-transform:uppercase;color:rgba(255,255,255,.45);font-weight:600;margin-bottom:18px}
.foot-grid ul{list-style:none;padding:0;margin:0}
.foot-grid li{margin-bottom:10px}
.foot-brand .brand{color:#fff;margin-bottom:18px}
.foot-brand .brand-mark{background:#fff;color:var(--ink)}
.foot-brand .brand-text span{color:rgba(255,255,255,.5)}
.social{display:flex;gap:10px;margin-top:22px}
.social a{width:40px;height:40px;border-radius:50%;border:1px solid rgba(255,255,255,.18);display:grid;place-items:center}
.social a:hover{background:#fff;color:var(--ink)}
.social svg{width:18px;height:18px}
.foot-bottom{display:flex;justify-content:space-between;gap:20px;flex-wrap:wrap;padding-top:28px;font-size:.82rem;color:rgba(255,255,255,.42)}
@media (max-width:900px){.foot-grid{grid-template-columns:1fr 1fr}}
@media (max-width:540px){.foot-grid{grid-template-columns:1fr}}

/* WhatsApp flotante */
.wa-float{position:fixed;right:20px;bottom:20px;z-index:40;width:56px;height:56px;border-radius:50%;background:#1fa855;color:#fff;display:grid;place-items:center;box-shadow:0 10px 26px -6px rgba(0,0,0,.35);transition:transform .2s}
.wa-float:hover{transform:scale(1.06);color:#fff}
.wa-float svg{width:28px;height:28px}

/* animación de entrada */
.reveal{opacity:0;transform:translateY(18px);transition:opacity .8s ease,transform .8s ease}
.reveal.in{opacity:1;transform:none}
@media (prefers-reduced-motion:reduce){.reveal{opacity:1;transform:none;transition:none}html{scroll-behavior:auto}}
.post-card .more svg,.crumbs svg{width:16px;height:16px;flex:0 0 16px}
svg{flex-shrink:0}